Unixime
Unixime Brand names, Unixime Analogs
Unixime Brand Names Mixture
- No information avaliable
Unixime Chemical_Formula
C16H15N5O7S2
Unixime RX_link
http://www.rxlist.com/cgi/generic/cefixime.htm
Unixime fda sheet
Unixime msds (material safety sheet)
Unixime Synthesis Reference
T. Takaya et al., U.S. Pat. 4,409,214 (1981)
Unixime Molecular Weight
453.452 g/mol
Unixime Melting Point
218-225 oC
Unixime H2O Solubility
55.11 mg/L
Unixime State
Solid
Unixime LogP
-0.559
Unixime Dosage Forms
Oral suspension (100 mg/5 mL); Tablet (200 mg and 400 mg); Powder for solution; Powder for suspension
Unixime Indication
For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Unixime Pharmacology
Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Unixime Absorption
About 40%-50% absorbed orally whether administered with or without food, however, time to maximal absorption is increased approximately 0.8 hours when administered with food.
Unixime side effects and Toxicity
Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.
Unixime Patient Information
Unixime Organisms Affected
Enteric bacteria and other eubacteria
