Univasc
Univasc Brand names, Univasc Analogs
Univasc Brand Names Mixture
- No information avaliable
Univasc Chemical_Formula
C66H83N17O13
Univasc RX_link
http://www.rxlist.com/cgi/generic2/nafarelin.htm
Univasc fda sheet
Univasc msds (material safety sheet)
Univasc Synthesis Reference
No information avaliable
Univasc Molecular Weight
1321.6344 g/mol
Univasc Melting Point
No information avaliable
Univasc H2O Solubility
No information avaliable
Univasc State
Solid
Univasc LogP
No information avaliable
Univasc Dosage Forms
Liquid; Metered-dose (aerosol)
Univasc Indication
For treatment of gonadotropin-dependent precocious puberty in children of both sexes and for the treatment of endometriosis.
Univasc Pharmacology
Nafarelin is a potent agonistic analog of gonadotropin-releasing hormone (GnRH). At the onset of administration, nafarelin stimulates the release of the pituitary gonadotropins, LH and FSH, resulting in a temporary increase of gonadal steroidogenesis. Repeated dosing abolishes the stimulatory effect on the pituitary gland. Twice daily administration leads to decreased secretion of gonadal steroids by about 4 weeks; consequently, tissues and functions that depend on gonadal steroids for their maintenance become quiescent. After nafarelin therapy is discontinued, pituitary and ovarian function normalize and estradiol serum concentrations increase to pretreatment levels. Recurrences of endometriosis are frequent after cessation of any hormonal therapy and after surgery that leaves the ovaries and/or uterus intact.
Univasc Absorption
Rapidly absorbed into the systemic circulation after intranasal administration. Bioavailability from a 400 µg dose averaged 2.8% (range 1.2 to 5.6%). Not absorbed after oral administration.
Univasc side effects and Toxicity
In experimental animals, a single subcutaneous administration of up to 60 times the recommended human dose (on a µg/kg basis, not adjusted for bioavailability) had no adverse effects. At present, there is no clinical evidence of adverse effects following overdosage of GnRH analogs.
Univasc Patient Information
Univasc Organisms Affected
Humans and other mammals
