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Sylvemid Brand names, Sylvemid Analogs

Sylvemid Brand Names Mixture

  • Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
  • Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
  • Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Sylvemid Chemical_Formula

C20H23N

Sylvemid RX_link

http://www.rxlist.com/cgi/generic/amitrip.htm

Sylvemid fda sheet

Sylvemid msds (material safety sheet)

Sylvemid MSDS

Sylvemid Synthesis Reference

Hoffsommer et al., J. Org. Chem. 27, 4134 (1962)

Sylvemid Molecular Weight

277.403 g/mol

Sylvemid Melting Point

196-197 oC

Sylvemid H2O Solubility

9.7 mg/mL

Sylvemid State

Solid

Sylvemid LogP

4.612

Sylvemid Dosage Forms

Syrup; Tablet (10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg)

Sylvemid Indication

For the treatment of anxiety, bipolar disorders, and depression.

Sylvemid Pharmacology

Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).

Sylvemid Absorption

Rapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism).

Sylvemid side effects and Toxicity

LD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma.

Sylvemid Patient Information

While on therapy with amitriptyline HCl, patients should be advised as to the possible impairment of mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

Sylvemid Organisms Affected

Humans and other mammals