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Amytriptiline Brand names, Amytriptiline Analogs

Amytriptiline Brand Names Mixture

  • Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
  • Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
  • Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Amytriptiline Chemical_Formula

C20H23N

Amytriptiline RX_link

http://www.rxlist.com/cgi/generic/amitrip.htm

Amytriptiline fda sheet

Amytriptiline msds (material safety sheet)

Amytriptiline MSDS

Amytriptiline Synthesis Reference

Hoffsommer et al., J. Org. Chem. 27, 4134 (1962)

Amytriptiline Molecular Weight

277.403 g/mol

Amytriptiline Melting Point

196-197 oC

Amytriptiline H2O Solubility

9.7 mg/mL

Amytriptiline State

Solid

Amytriptiline LogP

4.612

Amytriptiline Dosage Forms

Syrup; Tablet (10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg)

Amytriptiline Indication

For the treatment of anxiety, bipolar disorders, and depression.

Amytriptiline Pharmacology

Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).

Amytriptiline Absorption

Rapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism).

Amytriptiline side effects and Toxicity

LD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma.

Amytriptiline Patient Information

While on therapy with amitriptyline HCl, patients should be advised as to the possible impairment of mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

Amytriptiline Organisms Affected

Humans and other mammals