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Amitriptyline HCL Brand names, Amitriptyline HCL Analogs

Amitriptyline HCL Brand Names Mixture

  • Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
  • Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
  • Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Amitriptyline HCL Chemical_Formula

C20H23N

Amitriptyline HCL RX_link

http://www.rxlist.com/cgi/generic/amitrip.htm

Amitriptyline HCL fda sheet

Amitriptyline HCL msds (material safety sheet)

Amitriptyline_HCL MSDS

Amitriptyline HCL Synthesis Reference

Hoffsommer et al., J. Org. Chem. 27, 4134 (1962)

Amitriptyline HCL Molecular Weight

277.403 g/mol

Amitriptyline HCL Melting Point

196-197 oC

Amitriptyline HCL H2O Solubility

9.7 mg/mL

Amitriptyline HCL State

Solid

Amitriptyline HCL LogP

4.612

Amitriptyline HCL Dosage Forms

Syrup; Tablet (10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg)

Amitriptyline HCL Indication

For the treatment of anxiety, bipolar disorders, and depression.

Amitriptyline HCL Pharmacology

Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).

Amitriptyline HCL Absorption

Rapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism).

Amitriptyline HCL side effects and Toxicity

LD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma.

Amitriptyline HCL Patient Information

While on therapy with amitriptyline HCl, patients should be advised as to the possible impairment of mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

Amitriptyline HCL Organisms Affected

Humans and other mammals