Sucralfate
Sucralfate Brand names, Sucralfate Analogs
Sucralfate Brand Names Mixture
- No information avaliable
Sucralfate Chemical_Formula
C11H87Al9O55S8
Sucralfate RX_link
http://www.rxlist.com/cgi/generic/sucral.htm
Sucralfate fda sheet
Sucralfate msds (material safety sheet)
Sucralfate Synthesis Reference
No information avaliable
Sucralfate Molecular Weight
1599.14 g/mol
Sucralfate Melting Point
No information avaliable
Sucralfate H2O Solubility
Insoluble in cold water
Sucralfate State
Solid
Sucralfate LogP
No information avaliable
Sucralfate Dosage Forms
Suspension; Tablet for oral administration (1g)
Sucralfate Indication
For the short-term treatment (up to 8 weeks) of active duodenal ulcer. Also used as maintenance therapy for duodenal ulcer patients at reduced dosage (1 gram twice a day) after healing of acute ulcers.
Sucralfate Pharmacology
Sucralfate is a prescription medication used to treat peptic ulcers. The current clinical uses of sucralfate are limited. It is effective for the healing of duodenal ulcers, but it is not frequently used for this since more effective drugs (e.g. proton pump inhibitors) have been developed. Although the mechanism of sucralfate's ability to accelerate healing of duodenal ulcers remains to be fully defined, it is known that it exerts its effect through a local, rather than systemic, action. Chemically, sucralfate is a complex of the disaccharide sugar, sucrose, combined with sulfate and aluminum. In acidic solutions (e.g. gastric acid) it forms a thick paste that has a strong negative charge.
Sucralfate Absorption
Minimally absorbed from the gastrointestinal tract (up to 5% of the disaccharide component and less than 0.02% of aluminum).
Sucralfate side effects and Toxicity
Acute oral toxicity (LD50) in mice is >8000 mg/kg. There is limited experience in humans with overdosage of sucralfate. Sucralfate is only minimally absorbed from the gastrointestinal tract and thus risks associated with acute overdosage should be minimal. In rare reports describing sucralfate overdose, most patients remained asymptomatic.
Sucralfate Patient Information
Sucralfate Organisms Affected
Humans and other mammals
