Stimulexin
Stimulexin Brand names, Stimulexin Analogs
Stimulexin Brand Names Mixture
- No information avaliable
Stimulexin Chemical_Formula
C24H30N2O2
Stimulexin RX_link
http://www.rxlist.com/cgi/generic2/doxapram.htm
Stimulexin fda sheet
Stimulexin msds (material safety sheet)
Stimulexin Synthesis Reference
No information avaliable
Stimulexin Molecular Weight
378.507 g/mol
Stimulexin Melting Point
No information avaliable
Stimulexin H2O Solubility
Sparingly soluble
Stimulexin State
Solid
Stimulexin LogP
3.938
Stimulexin Dosage Forms
Liquid; Solution
Stimulexin Indication
For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Stimulexin Pharmacology
Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
Stimulexin Absorption
No information avaliable
Stimulexin side effects and Toxicity
Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Stimulexin Patient Information
No information avaliable
Stimulexin Organisms Affected
Humans and other mammals
