Doxapram hydrochloride en es it fr

Doxapram hydrochloride Brand names, Doxapram hydrochloride Analogs

Doxapram hydrochloride Brand Names Mixture

  • No information avaliable

Doxapram hydrochloride Chemical_Formula

C24H30N2O2

Doxapram hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/doxapram.htm

Doxapram hydrochloride fda sheet

Doxapram_hydrochloride FDA

Doxapram hydrochloride msds (material safety sheet)

Doxapram_hydrochloride MSDS

Doxapram hydrochloride Synthesis Reference

No information avaliable

Doxapram hydrochloride Molecular Weight

378.507 g/mol

Doxapram hydrochloride Melting Point

No information avaliable

Doxapram hydrochloride H2O Solubility

Sparingly soluble

Doxapram hydrochloride State

Solid

Doxapram hydrochloride LogP

3.938

Doxapram hydrochloride Dosage Forms

Liquid; Solution

Doxapram hydrochloride Indication

For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.

Doxapram hydrochloride Pharmacology

Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.

Doxapram hydrochloride Absorption

No information avaliable

Doxapram hydrochloride side effects and Toxicity

Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.

Doxapram hydrochloride Patient Information

No information avaliable

Doxapram hydrochloride Organisms Affected

Humans and other mammals