Dopram
Dopram Brand names, Dopram Analogs
Dopram Brand Names Mixture
- No information avaliable
Dopram Chemical_Formula
C24H30N2O2
Dopram RX_link
http://www.rxlist.com/cgi/generic2/doxapram.htm
Dopram fda sheet
Dopram msds (material safety sheet)
Dopram Synthesis Reference
No information avaliable
Dopram Molecular Weight
378.507 g/mol
Dopram Melting Point
No information avaliable
Dopram H2O Solubility
Sparingly soluble
Dopram State
Solid
Dopram LogP
3.938
Dopram Dosage Forms
Liquid; Solution
Dopram Indication
For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Dopram Pharmacology
Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
Dopram Absorption
No information avaliable
Dopram side effects and Toxicity
Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Dopram Patient Information
No information avaliable
Dopram Organisms Affected
Humans and other mammals
