Doxapram HCL
Doxapram HCL Brand names, Doxapram HCL Analogs
Doxapram HCL Brand Names Mixture
- No information avaliable
Doxapram HCL Chemical_Formula
C24H30N2O2
Doxapram HCL RX_link
http://www.rxlist.com/cgi/generic2/doxapram.htm
Doxapram HCL fda sheet
Doxapram HCL msds (material safety sheet)
Doxapram HCL Synthesis Reference
No information avaliable
Doxapram HCL Molecular Weight
378.507 g/mol
Doxapram HCL Melting Point
No information avaliable
Doxapram HCL H2O Solubility
Sparingly soluble
Doxapram HCL State
Solid
Doxapram HCL LogP
3.938
Doxapram HCL Dosage Forms
Liquid; Solution
Doxapram HCL Indication
For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Doxapram HCL Pharmacology
Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
Doxapram HCL Absorption
No information avaliable
Doxapram HCL side effects and Toxicity
Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Doxapram HCL Patient Information
No information avaliable
Doxapram HCL Organisms Affected
Humans and other mammals
