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Sildenafil Brand names, Sildenafil Analogs

Sildenafil Brand Names Mixture

  • No information avaliable

Sildenafil Chemical_Formula


Sildenafil RX_link

Sildenafil fda sheet

Sildenafil FDA

Sildenafil msds (material safety sheet)

Sildenafil MSDS

Sildenafil Synthesis Reference

Nicholas K. Terrett et al., Bioorganic & Medicinal Chemistry Letters, Vol 6, pp. 1819-1824 (1996)

Sildenafil Molecular Weight

474.578 g/mol

Sildenafil Melting Point

189-190 oC

Sildenafil H2O Solubility

3.5 mg/mL

Sildenafil State


Sildenafil LogP

No information avaliable

Sildenafil Dosage Forms


Sildenafil Indication

For the treatment of erectile dysfunction

Sildenafil Pharmacology

Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil should not cause an erection.

Sildenafil Absorption


Sildenafil side effects and Toxicity

No information avaliable

Sildenafil Patient Information

Sildenafil Organisms Affected

Humans and other mammals