Sildenafil Viagra

Sildenafil Viagra Brand names, Sildenafil Viagra Analogs

Sildenafil Viagra Brand Names Mixture

No information avaliable

Sildenafil Viagra Chemical_Formula

C₂₂H₃₀N₆O₄S

Sildenafil Viagra RX_link

http://www.rxlist.com/cgi/generic/viagra.htm

Sildenafil Viagra fda sheet

Sildenafil_Viagra FDA

Sildenafil Viagra msds (material safety sheet)

Sildenafil_Viagra MSDS

Sildenafil Viagra Synthesis Reference

Nicholas K. Terrett et al., Bioorganic & Medicinal Chemistry Letters, Vol 6, pp. 1819-1824 (1996)

Sildenafil Viagra Molecular Weight

474.578 g/mol

Sildenafil Viagra Melting Point

189-190 ^oC

Sildenafil Viagra H₂O Solubility

3.5 mg/mL

Sildenafil Viagra State

Solid

Sildenafil Viagra LogP

No information avaliable

Sildenafil Viagra Dosage Forms

Tablet

Sildenafil Viagra Indication

For the treatment of erectile dysfunction

Sildenafil Viagra Pharmacology

Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil should not cause an erection.

Sildenafil Viagra Absorption

~40%

Sildenafil Viagra side effects and Toxicity