Viagra

Viagra Brand names, Viagra Analogs

Viagra Brand Names Mixture

No information avaliable

Viagra Chemical_Formula

C₂₂H₃₀N₆O₄S

Viagra RX_link

http://www.rxlist.com/cgi/generic/viagra.htm

Viagra fda sheet

Viagra FDA

Viagra msds (material safety sheet)

Viagra MSDS

Viagra Synthesis Reference

Nicholas K. Terrett et al., Bioorganic & Medicinal Chemistry Letters, Vol 6, pp. 1819-1824 (1996)

Viagra Molecular Weight

474.578 g/mol

Viagra Melting Point

189-190 ^oC

Viagra H₂O Solubility

3.5 mg/mL

Viagra State

Solid

Viagra LogP

No information avaliable

Viagra Dosage Forms

Tablet

Viagra Indication

For the treatment of erectile dysfunction

Viagra Pharmacology

Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil should not cause an erection.

Viagra Absorption

~40%

Viagra side effects and Toxicity