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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C30H46NO7P
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RX_link
http://www.rxlist.com/cgi/generic/fosinop.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
E. W. Petrillo, Jr., U.S. Pat. 4,337,201 (1982)
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Molecular Weight
563.663 g/mol
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Melting Point
149-153oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
6.61
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Dosage Forms
Tablet
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Indication
For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics. It is alos indicated in the management of heart failure.
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Pharmacology
Fosinopril, an angiotensin-converting enzyme (ACE) inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. By blocking ACE, Fosinopril decreases angiotensin II which is a vasoconstrictor. Fosinopril is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.
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Absorption
~36% of an oral dose
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals