Rifapentine
Rifapentine Brand names, Rifapentine Analogs
Rifapentine Brand Names Mixture
- No information avaliable
Rifapentine Chemical_Formula
C47H64N4O12
Rifapentine RX_link
http://www.rxlist.com/cgi/generic/priftin.htm
Rifapentine fda sheet
Rifapentine msds (material safety sheet)
Rifapentine Synthesis Reference
No information avaliable
Rifapentine Molecular Weight
877.031 g/mol
Rifapentine Melting Point
No information avaliable
Rifapentine H2O Solubility
No information avaliable
Rifapentine State
Solid
Rifapentine LogP
5.29
Rifapentine Dosage Forms
No information avaliable
Rifapentine Indication
For the treatment of pulmonary tuberculosis.
Rifapentine Pharmacology
Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Rifapentine Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Rifapentine side effects and Toxicity
No information avaliable
Rifapentine Patient Information
No information avaliable
Rifapentine Organisms Affected
Mycobacterium
