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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C47H64N4O12
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RX_link
http://www.rxlist.com/cgi/generic/priftin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
877.031 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
5.29
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Dosage Forms
No information avaliable
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Indication
For the treatment of pulmonary tuberculosis.
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Pharmacology
Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
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Absorption
Rapidly and well absorbed from the gastrointestinal tract.
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Mycobacterium