Remeron
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H19N3
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RX_link
http://www.rxlist.com/cgi/generic/mirtaz.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
W. J. Van der Burg, U.S. Pat. 4,062,848 (1977)
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Molecular Weight
265.353 g/mol
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Melting Point
114-116oC
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H2O Solubility
Slight
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State
Solid
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LogP
2.369
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Dosage Forms
Tablet; Tablet (orally disintegrating)
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Indication
For the treatment of major depressive disorder.
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Pharmacology
Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.
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Absorption
Rapid and complete, but, due to first-pass metabolism, absolute bioavailability is 50%.
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side effects and Toxicity
Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50=mg/kg (orally in rat).
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Patient Information
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Organisms Affected
Humans and other mammals