Mepirzepine
Brand names,
Mepirzepine
Analogs
Mepirzepine
Brand Names Mixture
Mepirzepine
Chemical_Formula
C17H19N3
Mepirzepine
RX_link
http://www.rxlist.com/cgi/generic/mirtaz.htm
Mepirzepine
fda sheet
Mepirzepine
msds (material safety sheet)
Mepirzepine
Synthesis Reference
W. J. Van der Burg, U.S. Pat. 4,062,848 (1977)
Mepirzepine
Molecular Weight
265.353 g/mol
Mepirzepine
Melting Point
114-116oC
Mepirzepine
H2O Solubility
Slight
Mepirzepine
State
Solid
Mepirzepine
LogP
2.369
Mepirzepine
Dosage Forms
Tablet; Tablet (orally disintegrating)
Mepirzepine
Indication
For the treatment of major depressive disorder.
Mepirzepine
Pharmacology
Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.
Mepirzepine
Absorption
Rapid and complete, but, due to first-pass metabolism, absolute bioavailability is 50%.
Mepirzepine
side effects and Toxicity
Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50=mg/kg (orally in rat).
Mepirzepine
Patient Information
Mepirzepine
Organisms Affected
Humans and other mammals