Quetiapine fumarate

• Antipsychotics
• ATC:N05AH04

• Quetiapin hemifumarate
• Quetiapine fumarate
• Quetiapine hemifumarate
• Seroquel

• No information avaliable

C₂₁H₂₅N₃O₂S

http://www.rxlist.com/cgi/generic2/quetiap.htm

Quetiapine_fumarate FDA

Quetiapine_fumarate MSDS

No information avaliable

383.508 g/mol

No information avaliable

Moderate

Solid

2.296

Tablet

For the treatment of schizophrenia and acute manic episodes associated with bipolar I disorder, as either monotherapy or adjunct therapy to lithium or divalproex.

Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT₂), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT_1A and 5HT₂, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.

Rapidly and well absorbed.

Symptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.

Humans and other mammals