Quetiapin hemifumarate
Brand names,
Quetiapin hemifumarate
Analogs
Quetiapin hemifumarate
Brand Names Mixture
Quetiapin hemifumarate
Chemical_Formula
C21H25N3O2S
Quetiapin hemifumarate
RX_link
http://www.rxlist.com/cgi/generic2/quetiap.htm
Quetiapin hemifumarate
fda sheet
Quetiapin hemifumarate
msds (material safety sheet)
Quetiapin hemifumarate
Synthesis Reference
No information avaliable
Quetiapin hemifumarate
Molecular Weight
383.508 g/mol
Quetiapin hemifumarate
Melting Point
No information avaliable
Quetiapin hemifumarate
H2O Solubility
Moderate
Quetiapin hemifumarate
State
Solid
Quetiapin hemifumarate
LogP
2.296
Quetiapin hemifumarate
Dosage Forms
Tablet
Quetiapin hemifumarate
Indication
For the treatment of schizophrenia and acute manic episodes associated with bipolar I disorder, as either monotherapy or adjunct therapy to lithium or divalproex.
Quetiapin hemifumarate
Pharmacology
Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.
Quetiapin hemifumarate
Absorption
Rapidly and well absorbed.
Quetiapin hemifumarate
side effects and Toxicity
Symptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.
Quetiapin hemifumarate
Patient Information
Quetiapin hemifumarate
Organisms Affected
Humans and other mammals