Psorcon
Brand names,
Psorcon
Analogs
Psorcon
Brand Names Mixture
Psorcon
Chemical_Formula
C26H32F2O7
Psorcon
RX_link
http://www.rxlist.com/cgi/generic/diflorasone.htm
Psorcon
fda sheet
Psorcon
msds (material safety sheet)
Psorcon
Synthesis Reference
No information avaliable
Psorcon
Molecular Weight
494.525 g/mol
Psorcon
Melting Point
No information avaliable
Psorcon
H2O Solubility
No information avaliable
Psorcon
State
Solid
Psorcon
LogP
2.465
Psorcon
Dosage Forms
Cream; Ointment
Psorcon
Indication
For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Psorcon
Pharmacology
Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Psorcon
Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Psorcon
side effects and Toxicity
Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Psorcon
Patient Information
Psorcon
Organisms Affected
Humans and other mammals