Diflorasone Diacetate
Brand names,
Diflorasone Diacetate
Analogs
Diflorasone Diacetate
Brand Names Mixture
Diflorasone Diacetate
Chemical_Formula
C26H32F2O7
Diflorasone Diacetate
RX_link
http://www.rxlist.com/cgi/generic/diflorasone.htm
Diflorasone Diacetate
fda sheet
Diflorasone Diacetate
msds (material safety sheet)
Diflorasone Diacetate
Synthesis Reference
No information avaliable
Diflorasone Diacetate
Molecular Weight
494.525 g/mol
Diflorasone Diacetate
Melting Point
No information avaliable
Diflorasone Diacetate
H2O Solubility
No information avaliable
Diflorasone Diacetate
State
Solid
Diflorasone Diacetate
LogP
2.465
Diflorasone Diacetate
Dosage Forms
Cream; Ointment
Diflorasone Diacetate
Indication
For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Diflorasone Diacetate
Pharmacology
Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Diflorasone Diacetate
Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Diflorasone Diacetate
side effects and Toxicity
Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Diflorasone Diacetate
Patient Information
Diflorasone Diacetate
Organisms Affected
Humans and other mammals