Proconvertin
Brand names,
Proconvertin
Analogs
Proconvertin
Brand Names Mixture
Proconvertin
Chemical_Formula
C1972H3076N560O597S28
Proconvertin
RX_link
http://www.rxlist.com/cgi/generic3/novoseven.htm
Proconvertin
fda sheet
Proconvertin
msds (material safety sheet)
Proconvertin
Synthesis Reference
No information avaliable
Proconvertin
Molecular Weight
45079.1
Proconvertin
Melting Point
58 oC (Petersen, L.C. et al., Eur. J. Biochem 261: 124-129 (1999)).
Proconvertin
H2O Solubility
No information avaliable
Proconvertin
State
Liquid
Proconvertin
LogP
-0.311
Proconvertin
Dosage Forms
Solution (IV injection); Solution (IV infusion); Tablet; Powder for solution
Proconvertin
Indication
For treatment of hemorrhagic complications in hemophilia A and B
Proconvertin
Pharmacology
Used in the treatment of bleeding episodes in hemophilia A or B. NovoSeven is recombinant Factor VIIa and, when complexed with tissue factor can activate coagulation Factor X to Factor Xa, as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin, which leads to the formation of a hemostatic plug by converting fibrinogen to fibrin and thereby inducing local clotting.
Proconvertin
Absorption
No information avaliable
Proconvertin
side effects and Toxicity
No information avaliable
Proconvertin
Patient Information
No information avaliable
Proconvertin
Organisms Affected
Humans and other mammals