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Pralidoxime Brand names, Pralidoxime Analogs

Pralidoxime Brand Names Mixture

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Pralidoxime Chemical_Formula


Pralidoxime RX_link

Pralidoxime fda sheet

Pralidoxime FDA

Pralidoxime msds (material safety sheet)

Pralidoxime MSDS

Pralidoxime Synthesis Reference

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Pralidoxime Molecular Weight

137.159 g/mol

Pralidoxime Melting Point

215-225 oC

Pralidoxime H2O Solubility

No information avaliable

Pralidoxime State


Pralidoxime LogP


Pralidoxime Dosage Forms

Powder for solution

Pralidoxime Indication

For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.

Pralidoxime Pharmacology

Pralidoxime is to reactivate cholinesterase (mainly outside of the central nervous system) which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound. The destruction of accumulated acetylcholine can then proceed, and neuromuscular junctions will again function normally. Pralidoxime also slows the process of "aging" of phosphorylated cholinesterase to a nonreactivatable form, and detoxifies certain organophosphates by direct chemical reaction. The drug has its most critical effect in relieving paralysis of the muscles of respiration. Because pralidoxime is less effective in relieving depression of the respiratory center, atropine is always required concomitantly to block the effect of accumulated acetylcholine at this site. Pralidoxime relieves muscarinic signs and symptoms, salivation, bronchospasm, etc., but this action is relatively unimportant since atropine is adequate for this purpose.

Pralidoxime Absorption

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Pralidoxime side effects and Toxicity

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Pralidoxime Patient Information

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Pralidoxime Organisms Affected

Humans and other mammals