Perindopril

• Antidotes
• Cholinesterase Reactivators
• ATC:V03AB04

• Aceon
• Perindopril

• No information avaliable

C₇H₉N₂O+

http://www.rxlist.com/cgi/generic2/pralidoxime.htm

Perindopril FDA

Perindopril MSDS

No information avaliable

137.159 g/mol

215-225 ^oC

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Solid

1.564

Powder for solution

For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.

Pralidoxime is to reactivate cholinesterase (mainly outside of the central nervous system) which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound. The destruction of accumulated acetylcholine can then proceed, and neuromuscular junctions will again function normally. Pralidoxime also slows the process of "aging" of phosphorylated cholinesterase to a nonreactivatable form, and detoxifies certain organophosphates by direct chemical reaction. The drug has its most critical effect in relieving paralysis of the muscles of respiration. Because pralidoxime is less effective in relieving depression of the respiratory center, atropine is always required concomitantly to block the effect of accumulated acetylcholine at this site. Pralidoxime relieves muscarinic signs and symptoms, salivation, bronchospasm, etc., but this action is relatively unimportant since atropine is adequate for this purpose.

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Humans and other mammals