Picrotoxin
Picrotoxin Brand names, Picrotoxin Analogs
Picrotoxin Brand Names Mixture
- No information avaliable
Picrotoxin Chemical_Formula
C30H34O13
Picrotoxin RX_link
No information avaliable
Picrotoxin fda sheet
Picrotoxin msds (material safety sheet)
Picrotoxin Synthesis Reference
No information avaliable
Picrotoxin Molecular Weight
602.583 g/mol
Picrotoxin Melting Point
203.5 oC
Picrotoxin H2O Solubility
4100 mg/L
Picrotoxin State
Solid
Picrotoxin LogP
-2.229
Picrotoxin Dosage Forms
No information avaliable
Picrotoxin Indication
Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
Picrotoxin Pharmacology
Picrotoxin is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the GABAActivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.
Picrotoxin Absorption
No information avaliable
Picrotoxin side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg. In large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.
Picrotoxin Patient Information
No information avaliable
Picrotoxin Organisms Affected
Humans and other mammals
