TVFX
TVFX Brand names, TVFX Analogs
TVFX Brand Names Mixture
- No information avaliable
TVFX Chemical_Formula
C30H34O13
TVFX RX_link
No information avaliable
TVFX fda sheet
TVFX msds (material safety sheet)
TVFX Synthesis Reference
No information avaliable
TVFX Molecular Weight
602.583 g/mol
TVFX Melting Point
203.5 oC
TVFX H2O Solubility
4100 mg/L
TVFX State
Solid
TVFX LogP
-2.229
TVFX Dosage Forms
No information avaliable
TVFX Indication
Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
TVFX Pharmacology
Picrotoxin is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the GABAActivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.
TVFX Absorption
No information avaliable
TVFX side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg. In large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.
TVFX Patient Information
No information avaliable
TVFX Organisms Affected
Humans and other mammals
