PharmacyCodes



Trovan en es it fr

Trovan Brand names, Trovan Analogs

Trovan Brand Names Mixture

  • No information avaliable

Trovan Chemical_Formula

C30H34O13

Trovan RX_link

No information avaliable

Trovan fda sheet

Trovan msds (material safety sheet)

Trovan MSDS

Trovan Synthesis Reference

No information avaliable

Trovan Molecular Weight

602.583 g/mol

Trovan Melting Point

203.5 oC

Trovan H2O Solubility

4100 mg/L

Trovan State

Solid

Trovan LogP

-2.229

Trovan Dosage Forms

No information avaliable

Trovan Indication

Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.

Trovan Pharmacology

Picrotoxin is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the GABAActivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.

Trovan Absorption

No information avaliable

Trovan side effects and Toxicity

Oral, mouse: LD50 = 15 mg/kg. In large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.

Trovan Patient Information

No information avaliable

Trovan Organisms Affected

Humans and other mammals