Trovan
Trovan Brand names, Trovan Analogs
Trovan Brand Names Mixture
- No information avaliable
Trovan Chemical_Formula
C30H34O13
Trovan RX_link
No information avaliable
Trovan fda sheet
Trovan msds (material safety sheet)
Trovan Synthesis Reference
No information avaliable
Trovan Molecular Weight
602.583 g/mol
Trovan Melting Point
203.5 oC
Trovan H2O Solubility
4100 mg/L
Trovan State
Solid
Trovan LogP
-2.229
Trovan Dosage Forms
No information avaliable
Trovan Indication
Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
Trovan Pharmacology
Picrotoxin is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the GABAActivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.
Trovan Absorption
No information avaliable
Trovan side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg. In large doses it is a powerful poison, causing unconsciousness, delirium, convulsions, gastro-enteritis and stimulation of the respiratory centre followed by paralysis, from which death sometimes results.
Trovan Patient Information
No information avaliable
Trovan Organisms Affected
Humans and other mammals
