Paramethadione
Paramethadione Brand names, Paramethadione Analogs
Paramethadione Brand Names Mixture
- No information avaliable
Paramethadione Chemical_Formula
C7H11NO3
Paramethadione RX_link
No information avaliable
Paramethadione fda sheet
Paramethadione msds (material safety sheet)
Paramethadione Synthesis Reference
No information avaliable
Paramethadione Molecular Weight
157.167 g/mol
Paramethadione Melting Point
101.5 oC (boiling point)
Paramethadione H2O Solubility
8.4 mg/mL
Paramethadione State
Liquid
Paramethadione LogP
0.763
Paramethadione Dosage Forms
Tablet
Paramethadione Indication
Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Paramethadione Pharmacology
Paramethadione is an oxazolidinedione anticonvulsant similar to trimethadione that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics). Absence seizures involve an interruption to consciousness where the person experiencing the seizure seems to become vacant and unresponsive for a short period of time (usually up to 30 seconds). Paramethadione acts on thalamic neurons in the thalamic reticular nucleus (which studies have shown to be associated with absence seizures, von Krosigk et al., 1993).
Paramethadione Absorption
Rapid via the digestive tract.
Paramethadione side effects and Toxicity
Symptoms of overdose include clumsiness or unsteadiness, coma, severe dizziness, severe drowsiness, severe nausea, and problems with vision.
Paramethadione Patient Information
Dione anticonvulsants are used to control certain types of seizures in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures. These medicines cannot cure epilepsy and will only work to control seizures for as long as you continue to take them.
Paramethadione Organisms Affected
Humans and other mammals
