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Brand names,
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Analogs
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Brand Names Mixture
- Chromium with Niacin and Niacinamide-Liq (Chromium (Chromic Chloride) + Nicotinamide + Nicotinic Acid)
- Ff Formula Niacin & Inositol (Inositol + Nicotinic Acid)
- Flush Free Niacin with Inositol (Inositol (Inositol Hexanicotinate) + Nicotinic Acid)
- Lipofactors & Niacin (Choline (Choline Bitartrate) + Inositol + Nicotinic Acid)
- My Favorite Niacin and Inositol Tab (Inositol + Nicotinic Acid)
- Niacin 500 Mg and Inositol (Inositol + Nicotinic Acid)
- Niacin and Inositol (Inositol + Nicotinic Acid)
- Niacin Capsules with Chromium (Chromium + Nicotinic Acid)
- Niacin-Niacinamide Tab (Nicotinamide + Nicotinic Acid)
- No Flush Niacin with Inositol (Inositol (Inositol Hexanicotinate) + Nicotinic Acid)
- One a Day Advance High Pot.B Complex and C (Beta-Carotene + Copper (Cupric Oxide) + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Alpha Tocopheryl Acetate + Folic Acid + Iron (Ferrous Fumarate) + Nicotinamide (Niacin Ascorbate) + Thiamine Mononitrate + Vitamin a Acetate + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin D + Zinc (Zinc Oxide))
- One Tablet Daily High Potency B Complex and C (Beta-Carotene + Copper (Cupric Oxide) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron (Ferrous Fumarate) + Nicotinamide (Niacin Ascorbate) + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin D + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide))
- Primanol-Borage with Niacin and Chromium Tab (Chromium (Chromium Hvp Chelate) + Gamma-Linolenic Acid (Borage Oil) + Nicotinic Acid)
- Vitamin C with Niacin and Niacinamide-Liq (Nicotinamide + Nicotinic Acid + Vitamin C)
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Chemical_Formula
C6H5NO2
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RX_link
http://www.rxlist.com/cgi/generic3/niacor.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
123.109 g/mol
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Melting Point
237 oC
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H2O Solubility
1.8E+004 mg/L
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State
Solid
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LogP
0.225
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Dosage Forms
Capsule; Capsule (extended-release); Oral solution; Tablet; Tablet (extended-release); Injection
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Indication
For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy.
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Pharmacology
Niacin and niacinamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Niacin) also acts to reduce LDL cholesterol, triglycerides, and HDL cholesterol. The magnitude of individual lipid and lipoprotein responses may be influenced by the severity and type of underlying lipid abnormality. The increase in total HDL is associated with a shift in the distribution of HDL subfractions (as defined by ultra-centrifugation) with an increase in the HDL2:HDL3 ratio and an increase in apolipoprotein A-I content. Vitamin B3 (Niacin) treatment also decreases the serum levels of apolipoprotein B-100 (apo B), the major protein component of the VLDL (very low-density lipoprotein) and LDL fractions, and of lipoprotein-a, a variant form of LDL independently associated with coronary risk.
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Absorption
Both nicotinic acid and nicotinamide are efficiently absorbed from the stomach and small intestine
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side effects and Toxicity
Nicotinic acid can cause vasodilation of cutaneous blood vessels resulting in increased blood flow, principally in the face, neck and chest. This produces the niacin- or nicotinic acid-flush. The niacin-flush is thought to be mediated via the prostaglandin prostacyclin. Histamine may also play a role in the niacin-flush. Flushing is the adverse reaction first observed after intake of a large dose of nicotinic acid, and the most bothersome one. LD50 7000 mg/kg (Rat)
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Patient Information
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Organisms Affected
Humans and other mammals