Nicardipine HCl en es it fr

Nicardipine HCl Brand names, Nicardipine HCl Analogs

Nicardipine HCl Brand Names Mixture

  • No information avaliable

Nicardipine HCl Chemical_Formula

C26H29N3O6

Nicardipine HCl RX_link

http://www.rxlist.com/cgi/generic/nicardipine.htm

Nicardipine HCl fda sheet

Nicardipine_HCl FDA

Nicardipine HCl msds (material safety sheet)

Nicardipine_HCl MSDS

Nicardipine HCl Synthesis Reference

No information avaliable

Nicardipine HCl Molecular Weight

479.525 g/mol

Nicardipine HCl Melting Point

136-138 oC

Nicardipine HCl H2O Solubility

2.2 mg/L

Nicardipine HCl State

Solid

Nicardipine HCl LogP

3.967

Nicardipine HCl Dosage Forms

Capsule

Nicardipine HCl Indication

Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Nicardipine HCl Pharmacology

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Nicardipine HCl Absorption

While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.

Nicardipine HCl side effects and Toxicity

Oral LD50 Rat = 184 mg/kg, Oral LD50 Mouse = 322 mg/kg

Nicardipine HCl Patient Information

No information avaliable

Nicardipine HCl Organisms Affected

Humans and other mammals