Cardene SR

Cardene SR Brand names, Cardene SR Analogs

Cardene SR Brand Names Mixture

No information avaliable

Cardene SR Chemical_Formula

C₂₆H₂₉N₃O₆

Cardene SR RX_link

http://www.rxlist.com/cgi/generic/nicardipine.htm

Cardene SR fda sheet

Cardene_SR FDA

Cardene SR msds (material safety sheet)

Cardene_SR MSDS

Cardene SR Synthesis Reference

No information avaliable

Cardene SR Molecular Weight

479.525 g/mol

Cardene SR Melting Point

136-138 ^oC

Cardene SR H₂O Solubility

2.2 mg/L

Cardene SR State

Solid

Cardene SR LogP

3.967

Cardene SR Dosage Forms

Capsule

Cardene SR Indication

Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Cardene SR Pharmacology

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Cardene SR Absorption

While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.

Cardene SR side effects and Toxicity

Oral LD₅₀ Rat = 184 mg/kg, Oral LD₅₀ Mouse = 322 mg/kg

Cardene SR Patient Information