Nicardipine

Nicardipine Brand names, Nicardipine Analogs

Nicardipine Brand Names Mixture

No information avaliable

Nicardipine Chemical_Formula

C₂₆H₂₉N₃O₆

Nicardipine RX_link

http://www.rxlist.com/cgi/generic/nicardipine.htm

Nicardipine fda sheet

Nicardipine FDA

Nicardipine msds (material safety sheet)

Nicardipine MSDS

Nicardipine Synthesis Reference

No information avaliable

Nicardipine Molecular Weight

479.525 g/mol

Nicardipine Melting Point

136-138 ^oC

Nicardipine H₂O Solubility

2.2 mg/L

Nicardipine State

Solid

Nicardipine LogP

3.967

Nicardipine Dosage Forms

Capsule

Nicardipine Indication

Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Nicardipine Pharmacology

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Nicardipine Absorption

While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.

Nicardipine side effects and Toxicity

Oral LD₅₀ Rat = 184 mg/kg, Oral LD₅₀ Mouse = 322 mg/kg

Nicardipine Patient Information