Neomycin Sulfate
Brand names,
Neomycin Sulfate
Analogs
Neomycin Sulfate
Brand Names Mixture
Neomycin Sulfate
Chemical_Formula
C23H46N6O13
Neomycin Sulfate
RX_link
http://www.rxlist.com/cgi/generic3/neomy.htm
Neomycin Sulfate
fda sheet
Neomycin Sulfate
msds (material safety sheet)
Neomycin Sulfate
Synthesis Reference
No information avaliable
Neomycin Sulfate
Molecular Weight
614.644 g/mol
Neomycin Sulfate
Melting Point
6 mg/mL (as sulfate form)
Neomycin Sulfate
H2O Solubility
No information avaliable
Neomycin Sulfate
State
Solid
Neomycin Sulfate
LogP
-9.895
Neomycin Sulfate
Dosage Forms
Powder
Neomycin Sulfate
Indication
For the adjunctive treatment of acute hepatic failure, alcoholic cirrhosis of the liver, and suppression of intestinal bacteria.
Neomycin Sulfate
Pharmacology
Neomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Neomycin Sulfate
Absorption
Poorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Neomycin Sulfate
side effects and Toxicity
LD50 = 200 mg/kg (rat). Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity.
Neomycin Sulfate
Patient Information
Before administering the drug, patients or members of their families should be informed of possible toxic effects
on the eighth nerve. The possibility of acute toxicity increases in premature infants and neonates.
Neomycin Sulfate
Organisms Affected
Enteric bacteria and other eubacteria