Caswell No. 595
Brand names,
Caswell No. 595
Analogs
Caswell No. 595
Brand Names Mixture
Caswell No. 595
Chemical_Formula
C23H46N6O13
Caswell No. 595
RX_link
http://www.rxlist.com/cgi/generic3/neomy.htm
Caswell No. 595
fda sheet
Caswell No. 595
msds (material safety sheet)
Caswell No. 595
Synthesis Reference
No information avaliable
Caswell No. 595
Molecular Weight
614.644 g/mol
Caswell No. 595
Melting Point
6 mg/mL (as sulfate form)
Caswell No. 595
H2O Solubility
No information avaliable
Caswell No. 595
State
Solid
Caswell No. 595
LogP
-9.895
Caswell No. 595
Dosage Forms
Powder
Caswell No. 595
Indication
For the adjunctive treatment of acute hepatic failure, alcoholic cirrhosis of the liver, and suppression of intestinal bacteria.
Caswell No. 595
Pharmacology
Neomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Caswell No. 595
Absorption
Poorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Caswell No. 595
side effects and Toxicity
LD50 = 200 mg/kg (rat). Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity.
Caswell No. 595
Patient Information
Before administering the drug, patients or members of their families should be informed of possible toxic effects
on the eighth nerve. The possibility of acute toxicity increases in premature infants and neonates.
Caswell No. 595
Organisms Affected
Enteric bacteria and other eubacteria