Neogidrin
Neogidrin Brand names, Neogidrin Analogs
Neogidrin Brand Names Mixture
- No information avaliable
Neogidrin Chemical_Formula
C11H28ClN5O
Neogidrin RX_link
http://www.rxlist.com/cgi/generic/colestipol.htm
Neogidrin fda sheet
Neogidrin msds (material safety sheet)
Neogidrin Synthesis Reference
No information avaliable
Neogidrin Molecular Weight
281.826 g/mol
Neogidrin Melting Point
No information avaliable
Neogidrin H2O Solubility
Insoluble
Neogidrin State
Solid
Neogidrin LogP
-2.206
Neogidrin Dosage Forms
Tablets containing 1 gram of colestipol hydrochloride (light yellow in color and are tasteless and odorless)
Neogidrin Indication
For use, as adjunctive therapy to diet, for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet.
Neogidrin Pharmacology
Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. Colestipol hydrochloride binds bile acids in the intestine forming a complex that is excreted in the feces. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption. Since colestipol hydrochloride is an anion exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than the chloride ion.
Neogidrin Absorption
Not absorbed from the gastrointestinal tract.
Neogidrin side effects and Toxicity
Oral LD50 in rats is > 1000 mg/kg. Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colestipol is not absorbed, the risk of systemic toxicity is low.
Neogidrin Patient Information
Neogidrin Organisms Affected
Humans and other mammals
