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Katonil Brand names, Katonil Analogs

Katonil Brand Names Mixture

  • No information avaliable

Katonil Chemical_Formula


Katonil RX_link


Katonil fda sheet

Katonil msds (material safety sheet)

Katonil MSDS

Katonil Synthesis Reference

No information avaliable

Katonil Molecular Weight

281.826 g/mol

Katonil Melting Point

No information avaliable

Katonil H2O Solubility


Katonil State


Katonil LogP


Katonil Dosage Forms

Tablets containing 1 gram of colestipol hydrochloride (light yellow in color and are tasteless and odorless)

Katonil Indication

For use, as adjunctive therapy to diet, for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet.

Katonil Pharmacology

Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. Colestipol hydrochloride binds bile acids in the intestine forming a complex that is excreted in the feces. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption. Since colestipol hydrochloride is an anion exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than the chloride ion.

Katonil Absorption

Not absorbed from the gastrointestinal tract.

Katonil side effects and Toxicity

Oral LD50 in rats is > 1000 mg/kg. Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colestipol is not absorbed, the risk of systemic toxicity is low.

Katonil Patient Information

Katonil Organisms Affected

Humans and other mammals