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Diurone Brand names, Diurone Analogs

Diurone Brand Names Mixture

  • No information avaliable

Diurone Chemical_Formula


Diurone RX_link


Diurone fda sheet

Diurone msds (material safety sheet)

Diurone MSDS

Diurone Synthesis Reference

No information avaliable

Diurone Molecular Weight

281.826 g/mol

Diurone Melting Point

No information avaliable

Diurone H2O Solubility


Diurone State


Diurone LogP


Diurone Dosage Forms

Tablets containing 1 gram of colestipol hydrochloride (light yellow in color and are tasteless and odorless)

Diurone Indication

For use, as adjunctive therapy to diet, for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet.

Diurone Pharmacology

Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. Colestipol hydrochloride binds bile acids in the intestine forming a complex that is excreted in the feces. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption. Since colestipol hydrochloride is an anion exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than the chloride ion.

Diurone Absorption

Not absorbed from the gastrointestinal tract.

Diurone side effects and Toxicity

Oral LD50 in rats is > 1000 mg/kg. Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colestipol is not absorbed, the risk of systemic toxicity is low.

Diurone Patient Information

Diurone Organisms Affected

Humans and other mammals