Merculest
Merculest Brand names, Merculest Analogs
Merculest Brand Names Mixture
- No information avaliable
Merculest Chemical_Formula
C11H28ClN5O
Merculest RX_link
http://www.rxlist.com/cgi/generic/colestipol.htm
Merculest fda sheet
Merculest msds (material safety sheet)
Merculest Synthesis Reference
No information avaliable
Merculest Molecular Weight
281.826 g/mol
Merculest Melting Point
No information avaliable
Merculest H2O Solubility
Insoluble
Merculest State
Solid
Merculest LogP
-2.206
Merculest Dosage Forms
Tablets containing 1 gram of colestipol hydrochloride (light yellow in color and are tasteless and odorless)
Merculest Indication
For use, as adjunctive therapy to diet, for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet.
Merculest Pharmacology
Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating absorption. A major portion of the bile acids secreted is reabsorbed from the intestines and returned via the portal circulation to the liver, thus completing the enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. Colestipol hydrochloride binds bile acids in the intestine forming a complex that is excreted in the feces. This nonsystemic action results in a partial removal of the bile acids from the enterohepatic circulation, preventing their reabsorption. Since colestipol hydrochloride is an anion exchange resin, the chloride anions of the resin can be replaced by other anions, usually those with a greater affinity for the resin than the chloride ion.
Merculest Absorption
Not absorbed from the gastrointestinal tract.
Merculest side effects and Toxicity
Oral LD50 in rats is > 1000 mg/kg. Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colestipol is not absorbed, the risk of systemic toxicity is low.
Merculest Patient Information
Merculest Organisms Affected
Humans and other mammals
