NAD(+--diphthamide ADP- ribosyltransferase)
NAD(+--diphthamide ADP- ribosyltransferase) Brand names, NAD(+--diphthamide ADP- ribosyltransferase) Analogs
NAD(+--diphthamide ADP- ribosyltransferase) Brand Names Mixture
- No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) Chemical_Formula
C2560H4042N678O799S17
NAD(+--diphthamide ADP- ribosyltransferase) RX_link
http://www.rxlist.com/cgi/generic2/denileukin.htm
NAD(+--diphthamide ADP- ribosyltransferase) fda sheet
NAD(+--diphthamide ADP- ribosyltransferase) msds (material safety sheet)
NAD(+--diphthamide ADP- ribosyltransferase) Synthesis Reference
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) Molecular Weight
57647.3
NAD(+--diphthamide ADP- ribosyltransferase) Melting Point
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) H2O Solubility
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) State
Liquid
NAD(+--diphthamide ADP- ribosyltransferase) LogP
-0.301
NAD(+--diphthamide ADP- ribosyltransferase) Dosage Forms
Solution (IV Infusion)
NAD(+--diphthamide ADP- ribosyltransferase) Indication
For treatment of cutaneous T-cell lymphoma
NAD(+--diphthamide ADP- ribosyltransferase) Pharmacology
Denileukin diftitox (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.
NAD(+--diphthamide ADP- ribosyltransferase) Absorption
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) side effects and Toxicity
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) Patient Information
No information avaliable
NAD(+--diphthamide ADP- ribosyltransferase) Organisms Affected
Humans and other mammals
