Ontak (Seragen Inc)
Ontak (Seragen Inc) Brand names, Ontak (Seragen Inc) Analogs
Ontak (Seragen Inc) Brand Names Mixture
- No information avaliable
Ontak (Seragen Inc) Chemical_Formula
C2560H4042N678O799S17
Ontak (Seragen Inc) RX_link
http://www.rxlist.com/cgi/generic2/denileukin.htm
Ontak (Seragen Inc) fda sheet
Ontak (Seragen Inc) msds (material safety sheet)
Ontak (Seragen Inc) Synthesis Reference
No information avaliable
Ontak (Seragen Inc) Molecular Weight
57647.3
Ontak (Seragen Inc) Melting Point
No information avaliable
Ontak (Seragen Inc) H2O Solubility
No information avaliable
Ontak (Seragen Inc) State
Liquid
Ontak (Seragen Inc) LogP
-0.301
Ontak (Seragen Inc) Dosage Forms
Solution (IV Infusion)
Ontak (Seragen Inc) Indication
For treatment of cutaneous T-cell lymphoma
Ontak (Seragen Inc) Pharmacology
Denileukin diftitox (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.
Ontak (Seragen Inc) Absorption
No information avaliable
Ontak (Seragen Inc) side effects and Toxicity
No information avaliable
Ontak (Seragen Inc) Patient Information
No information avaliable
Ontak (Seragen Inc) Organisms Affected
Humans and other mammals
