DT
DT Brand names, DT Analogs
DT Brand Names Mixture
- No information avaliable
DT Chemical_Formula
C6H10N6O
DT RX_link
http://www.rxlist.com/cgi/generic2/dacarbazine.htm
DT fda sheet
DT msds (material safety sheet)
DT Synthesis Reference
Zambito et al.; Nucleic Acid Chem.; 1978; 3,8,9,10(1978);.
DT Molecular Weight
182.183 g/mol
DT Melting Point
205 oC
DT H2O Solubility
4220 mg/L
DT State
Solid
DT LogP
-1.938
DT Dosage Forms
Liquid; Powder for solution
DT Indication
For the treatment of metastatic malignant melanoma. In addition, DTIC-Dome is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other effective agents
DT Pharmacology
After intravenous administration of DTIC-Dome, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations DTIC is not appreciably bound to human plasma protein.
DT Absorption
Erratic, slow and incomplete
DT side effects and Toxicity
LD50=350mg/kg (orally in mice)
DT Patient Information
This medicine is a type of chemotherapy for treating cancers of the
blood and certain other cancers. This medicine interfers with the way
cancer cells grow, Take your doses on a regular scheduled time and DO
NOT take this medicine more often than directed by your health care
provider. Finish the full course prescribed by your health care provider.
DO NOT stop taking this medicine unless diredted to do so by your health
care provider. While taking this medicine, you make get infection more
easily. Call your doctor if you get a fever, chills, or sore throat.
Drink plenty of water with this medicine.
blood and certain other cancers. This medicine interfers with the way
cancer cells grow, Take your doses on a regular scheduled time and DO
NOT take this medicine more often than directed by your health care
provider. Finish the full course prescribed by your health care provider.
DO NOT stop taking this medicine unless diredted to do so by your health
care provider. While taking this medicine, you make get infection more
easily. Call your doctor if you get a fever, chills, or sore throat.
Drink plenty of water with this medicine.
DT Organisms Affected
Humans and other mammals
