Muran
Muran Brand names, Muran Analogs
Muran Brand Names Mixture
- No information avaliable
Muran Chemical_Formula
C9H7N7O2S
Muran RX_link
http://www.rxlist.com/cgi/generic/azathioprine.htm
Muran fda sheet
Muran msds (material safety sheet)
Muran Synthesis Reference
No information avaliable
Muran Molecular Weight
277.264 g/mol
Muran Melting Point
243.5 oC
Muran H2O Solubility
272 mg/L
Muran State
Solid
Muran LogP
1.001
Muran Dosage Forms
Powder for solution and tablets for oral administration (25 mg, 75 mg and 100 mg)
Muran Indication
For use as an adjunct in the prevention of rejection in renal homotransplantation. Also for the management of severe, active rheumatoid arthritis unresponsive to rest, aspirin or other nonsteroidal anti-inflammatory drugs, or to agents in the class of which gold is an example.
Muran Pharmacology
Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation and autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease or Crohn's disease. It is a pro-drug, converted in the body to the active metabolite 6-mercaptopurine. Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. It is a safe and effective drug used alone in certain autoimmune diseases, or in combination with other immunosuppressants in organ transplantation. Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogues such as allopurinol. The enzyme thiopurine S-methyltransferase (TPMT) deactivates 6-mercaptopurine. Genetic polymorphisms of TPMT can lead to excessive drug toxicity, thus assay of serum TPMT may be useful to prevent this complication.
Muran Absorption
Well absorbed following oral administration.
Muran side effects and Toxicity
The oral LD50 for single doses of azathioprine in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Very large doses of this antimetabolite may lead to marrow hypoplasia, bleeding, infection, and death.
Muran Patient Information
Muran Organisms Affected
Humans and other mammals
