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Azathioprin Brand names, Azathioprin Analogs

Azathioprin Brand Names Mixture

  • No information avaliable

Azathioprin Chemical_Formula


Azathioprin RX_link

Azathioprin fda sheet

Azathioprin msds (material safety sheet)

Azathioprin MSDS

Azathioprin Synthesis Reference

No information avaliable

Azathioprin Molecular Weight

277.264 g/mol

Azathioprin Melting Point

243.5 oC

Azathioprin H2O Solubility

272 mg/L

Azathioprin State


Azathioprin LogP


Azathioprin Dosage Forms

Powder for solution and tablets for oral administration (25 mg, 75 mg and 100 mg)

Azathioprin Indication

For use as an adjunct in the prevention of rejection in renal homotransplantation. Also for the management of severe, active rheumatoid arthritis unresponsive to rest, aspirin or other nonsteroidal anti-inflammatory drugs, or to agents in the class of which gold is an example.

Azathioprin Pharmacology

Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation and autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease or Crohn's disease. It is a pro-drug, converted in the body to the active metabolite 6-mercaptopurine. Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. It is a safe and effective drug used alone in certain autoimmune diseases, or in combination with other immunosuppressants in organ transplantation. Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogues such as allopurinol. The enzyme thiopurine S-methyltransferase (TPMT) deactivates 6-mercaptopurine. Genetic polymorphisms of TPMT can lead to excessive drug toxicity, thus assay of serum TPMT may be useful to prevent this complication.

Azathioprin Absorption

Well absorbed following oral administration.

Azathioprin side effects and Toxicity

The oral LD50 for single doses of azathioprine in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Very large doses of this antimetabolite may lead to marrow hypoplasia, bleeding, infection, and death.

Azathioprin Patient Information

Azathioprin Organisms Affected

Humans and other mammals