Meclastin

Meclastin Brand names, Meclastin Analogs

Meclastin Brand Names Mixture

Xalacom (Latanoprost + Timolol Maleate)

Meclastin Chemical_Formula

C₂₁H₂₆ClNO

Meclastin RX_link

http://www.rxlist.com/cgi/generic3/clemast.htm

Meclastin fda sheet

Meclastin msds (material safety sheet)

Meclastin MSDS

Meclastin Synthesis Reference

No information avaliable

Meclastin Molecular Weight

343.89 g/mol

Meclastin Melting Point

178 ^oC (hydrogen fumarate formulation)

Meclastin H₂O Solubility

Soluble (hydrogen fumarate formulation)

Meclastin State

Solid

Meclastin LogP

5.789

Meclastin Dosage Forms

Syrup (0.5 mg drug per 5mL syrup) and tablet (oral, 1mg)

Meclastin Indication

For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation.

Meclastin Pharmacology

Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.

Meclastin Absorption

Rapidly absorbed from the gastrointestinal tract.

Meclastin side effects and Toxicity

Oral LD₅₀ in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.

Meclastin Patient Information