Mecloprodin
Mecloprodin Brand names, Mecloprodin Analogs
Mecloprodin Brand Names Mixture
- Xalacom (Latanoprost + Timolol Maleate)
Mecloprodin Chemical_Formula
C21H26ClNO
Mecloprodin RX_link
http://www.rxlist.com/cgi/generic3/clemast.htm
Mecloprodin fda sheet
Mecloprodin msds (material safety sheet)
Mecloprodin Synthesis Reference
No information avaliable
Mecloprodin Molecular Weight
343.89 g/mol
Mecloprodin Melting Point
178 oC (hydrogen fumarate formulation)
Mecloprodin H2O Solubility
Soluble (hydrogen fumarate formulation)
Mecloprodin State
Solid
Mecloprodin LogP
5.789
Mecloprodin Dosage Forms
Syrup (0.5 mg drug per 5mL syrup) and tablet (oral, 1mg)
Mecloprodin Indication
For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation.
Mecloprodin Pharmacology
Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.
Mecloprodin Absorption
Rapidly absorbed from the gastrointestinal tract.
Mecloprodin side effects and Toxicity
Oral LD50 in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.
Mecloprodin Patient Information
No information avaliable
Mecloprodin Organisms Affected
Humans and other mammals
