Loperamide

• Antidiarrheals
• ATC:A07DA03
• ATC:A07DA05

• Apo-Loperamide
• Diarr-Eze
• Imodium
• Imodium A-D
• Imodium A-D Caplets
• Ioperamide
• Kaopectate II
• Loperacap
• Loperamida [INN-Spanish]
• Loperamide HCL
• Loperamidum [INN-Latin]
• Maalox Anti-Diarrheal
• Nu-Loperamide
• PMS-Loperamide
• Pepto Diarrhea Control
• Rho-Loperamide

• No information avaliable

C₂₉H₃₃ClN₂O₂

http://www.rxlist.com/cgi/generic3/loperamide.htm

Loperamide FDA

Loperamide MSDS

No information avaliable

477.037 g/mol

228 ^oC

Slight

Solid

6.249

Capsule; Liquid; Tablet

For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.

Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

Not significantly absorbed from the gut

Oral, mouse: LD₅₀ = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Patients should be advised to check with their physician if their diarrhea does not improve after a couple of days or if they note blood in their stools or develop a fever.

Humans and other mammals