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Imodium Brand names, Imodium Analogs

Imodium Brand Names Mixture

  • No information avaliable

Imodium Chemical_Formula

C29H33ClN2O2

Imodium RX_link

http://www.rxlist.com/cgi/generic3/loperamide.htm

Imodium fda sheet

Imodium FDA

Imodium msds (material safety sheet)

Imodium MSDS

Imodium Synthesis Reference

No information avaliable

Imodium Molecular Weight

477.037 g/mol

Imodium Melting Point

228 oC

Imodium H2O Solubility

Slight

Imodium State

Solid

Imodium LogP

6.249

Imodium Dosage Forms

Capsule; Liquid; Tablet

Imodium Indication

For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.

Imodium Pharmacology

Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

Imodium Absorption

Not significantly absorbed from the gut

Imodium side effects and Toxicity

Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Imodium Patient Information

Patients should be advised to check with their physician if their diarrhea does not improve after a couple of days or if they note blood in their stools or develop a fever.

Imodium Organisms Affected

Humans and other mammals