Kaopectate II en es it fr

Kaopectate II Brand names, Kaopectate II Analogs

Kaopectate II Brand Names Mixture

  • No information avaliable

Kaopectate II Chemical_Formula

C29H33ClN2O2

Kaopectate II RX_link

http://www.rxlist.com/cgi/generic3/loperamide.htm

Kaopectate II fda sheet

Kaopectate_II FDA

Kaopectate II msds (material safety sheet)

Kaopectate_II MSDS

Kaopectate II Synthesis Reference

No information avaliable

Kaopectate II Molecular Weight

477.037 g/mol

Kaopectate II Melting Point

228 oC

Kaopectate II H2O Solubility

Slight

Kaopectate II State

Solid

Kaopectate II LogP

6.249

Kaopectate II Dosage Forms

Capsule; Liquid; Tablet

Kaopectate II Indication

For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.

Kaopectate II Pharmacology

Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

Kaopectate II Absorption

Not significantly absorbed from the gut

Kaopectate II side effects and Toxicity

Oral, mouse: LD50 = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Kaopectate II Patient Information

Patients should be advised to check with their physician if their diarrhea does not improve after a couple of days or if they note blood in their stools or develop a fever.

Kaopectate II Organisms Affected

Humans and other mammals