Loperamidum [INN-Latin]

Loperamidum [INN-Latin] Brand names, Loperamidum [INN-Latin] Analogs

Loperamidum [INN-Latin] Brand Names Mixture

No information avaliable

Loperamidum [INN-Latin] Chemical_Formula

C₂₉H₃₃ClN₂O₂

Loperamidum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic3/loperamide.htm

Loperamidum [INN-Latin] fda sheet

Loperamidum_[INN-Latin] FDA

Loperamidum [INN-Latin] msds (material safety sheet)

Loperamidum_[INN-Latin] MSDS

Loperamidum [INN-Latin] Synthesis Reference

No information avaliable

Loperamidum [INN-Latin] Molecular Weight

477.037 g/mol

Loperamidum [INN-Latin] Melting Point

228 ^oC

Loperamidum [INN-Latin] H₂O Solubility

Slight

Loperamidum [INN-Latin] State

Solid

Loperamidum [INN-Latin] LogP

6.249

Loperamidum [INN-Latin] Dosage Forms

Capsule; Liquid; Tablet

Loperamidum [INN-Latin] Indication

For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.

Loperamidum [INN-Latin] Pharmacology

Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Loperamide is also indicated for reducing the volume of discharge from ileostomies. In man, Loperamide prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids. It works specifically by decreasing the activity of the myenteric plexus which decreases the motility of the circular and longitudinal smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

Loperamidum [INN-Latin] Absorption

Not significantly absorbed from the gut

Loperamidum [INN-Latin] side effects and Toxicity

Oral, mouse: LD₅₀ = 105 mg/kg. Symptoms of overdose include constipation, drowsiness, lethargy, and nausea.

Loperamidum [INN-Latin] Patient Information

Patients should be advised to check with their physician if their diarrhea does not improve after a couple of days or if they note blood in their stools or develop a fever.

Loperamidum [INN-Latin] Organisms Affected

Humans and other mammals